Prednisolone 5mg Soluble Tablets Patient Information Leaflet PIL emc

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Cortisolused for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Initiation and maintenance of prescribing in Primary Care following recommendation from a Specialist. Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate. To avoid errors with wrong liquid strength being prescribed please always prescribe the dose in mg rather then mls. If you can find a product cheaper elsewhere, call us with the details and most times we will either match or better the price.

In patients who have received more than physiological doses of systemic corticosteroids (approximately 7.5mg prednisolone or equivalent) for greater than three weeks, withdrawal should not be abrupt. How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced. Clinical assessment of disease activity may be needed during withdrawal. If the disease is unlikely to relapse on withdrawal of systemic corticosteroids but there is uncertainty about HPA suppression, the dose of systemic corticosteroid may be reduced rapidly to physiological doses. Once a daily dose equivalent to 7.5mg prednisolone is reached, dose reduction should be slower to allow the HPA axis to recover. Adrenal cortical atrophy develops during prolonged therapy and may persist for years after stopping treatment.

This will signify that a product is not recommended for prescribing in both primary and secondary care. All new products are classified as RED-RED pending assessment by PACEF. Medicines that should be initiated by a specialist and prescribed by primary care prescribers only under a shared care protocol.

The renal clearance of salicylates is increased by corticosteroids and steroid withdrawal may result in salicylate intoxication. Oestrogens and other oral contraceptives may potentiate the effects of glucocorticoids and dosage adjustments may be required if oral contraceptives are added to or withdrawn from a stable dosage regimen. Rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone, ephedrine and aminoglutethimide enhance the metabolism of corticosteroids and its therapeutic effects may be reduced. For children under 2 years, Prednisolone Soluble Tablets can be used early in the management of moderate to severe episodes of acute asthma in the hospital setting, at a dose of 10mg for up to three days. For doses under 5mg the 5mg/5ml oral solution will be more appropriate.

Particular care is required when considering the use of systemic corticosteroids in patients with existing or a previous history of severe affective disorders in themselves or in their first degree relatives. These would include depressive or manic-depressive illness and previous steroid psychosis. This will signify that a product has been approved for use within secondary or tertiary care, or by a primary care hosted specialist service only and should not be routinely prescribed in primary care. RED drugs may be used within ULHT or LPFT subject to approval for use within each trust. ULHT and LPFT reserve the right to determine whether or not RED drugs will be used within their trusts. RED classification does not automatically signify that a drug will be available within secondary/tertiary care.